Lincomycin first draft prepared by richard ellis, washington. Lincomycin hydrochloride soluble powder ireland oel twas 6 mgm3 2. Find patient medical information for lincomycin injection on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Lincocin lincomycin hydrochloride dose, indications. Lincomycin hydrochloride, monohydrate msds special notice. Other requirements where the label states that lincomycin hydrochloride is sterile,it meets the requirements for sterility and bacterial endotoxins under lincomycin injection. Lincocin is indicated for the treatment of localized infections, such as abscesses, pneumonitis, and feline rhinotracheitis. A validated stabilityindicating hplc method for routine. Each ml containing lincomycin hydrochloride equivalent to lincomycin, 50 mg.
Out of scope information includes radiopharmaceuticals, contrast media, herbals, homeopathics, and food. Lincomycin definition of lincomycin by the free dictionary. In rats and mice, the acute oral ld50 of different pharmacopoeial and premix grades of lincomycin hydrochloride. An antibiotic produced by streptomyces lincolnensis var. Jul 02, 2018 lincomycin hydrochloride pharmacokinetics absorption bioavailability. Lincomycin hydrochloride soluble powder for animal use. Clindamycin hydrochloride is the hydrated hydrochloride salt of clindamycin. Nov 09, 2018 lincomycin is an antibiotic that fights bacteria. Lincomycin hydrochloride monograph for professionals. Lincomycin hydrochloride is effective against grampositive bacteria. Lincomycin hydrochloride anhydrous is the anhydrous hydrochloride salt form of lincomycin, a lincosamide antibiotic originally identified in actinomycete streptomyces lincolnensis with activity against grampositive cocci and anaerobic bacteria. Lincomycin inhibits bacterial protein synthesis by forming crosslinks within the peptidyl transferase loop region of the 23s rrna. In clinical studies, this dose rate provided an average of 3.
The molecular formula of lincomycin hydrochloride is c18h34n2o6s. Clindamycin is a semisynthetic antibiotic produced by a 7schlorosubstitution of the 7rhydroxyl group of the parent compound lincomycin. Overall summary of the scientific evaluation of lincocin. Lincomycin hydrochloride market by product and end user. Lincocin has caused rare, but sometimes fatal intestinal problems. Cleocin hcl capsules contain clindamycin hydrochloride equivalent to 75 mg, 150 mg or 300 mg of clindamycin. Dailymed lincomycin lincomycin hydrochloride powder, for.
Lincomycin is a lincosamide antibiotic that comes from the actinomycete streptomyces lincolnensis. Side effects are rash, itching, nausea, vomiting, and diarrhea. List of drug master files dmf of lincomycin hydrochloride active pharmaceutical ingredient api submitted to the u. Lincomycin hydrochloride, brand name lincocin, is an injectable antibiotic used to treat serious infections that havent responded to other penicillins. May 16, 2019 lincomycin lincomycin hydrochloride powder, for solution out of scope out of scope for rxnorm and will not receive rxnorm normal forms. Stability studies of lincomycin hydrochloride in aqueous solution and.
Lincomycin is injected into a muscle, or into a vein through an iv. W is the weight, in mg, of the portion of lincomycin hydrochloride taken to prepare the assay preparation. Pdf stability studies of lincomycin hydrochloride in aqueous. It has a role as an antimicrobial agent and a bacterial metabolite. To reduce the development of drugresistant bacteria and maintain the effectiveness of lincocin and other antibacterial drugs, lincocin should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria.
Clindamycin is prepared as the hydrochloride salt of the base in 75, 150, and 300mg capsules and of the palmitate ester as a powder for pediatric suspension 75 mg5 ml. Topically applied lincomycin for acne jama dermatology. Lincomycin hydrochloride is a white or practically white, crystalline powder and is odorless or has a faint odor. Administer at a dose rate of 250 mg of lincomycin per gallon of drinking water.
The harmonized system hs code provided on this webpage are for information purposes only and are subject to change without notice. Lincocin sterile solution contains lincomycin hydrochloride which is the monohydrated salt of lincomycin, a substance produced by the growth of a member of the lincolnensis group of streptomyces lincolnensis fam. The chemical name for lincomycin hydrochloride is methyl 6,8dideoxy61methyltrans4propyll2. P is the designated potency, in g of lincomycin per mg, of usp lincomycin hydrochloride rs. Lincomycin hydrochloride is an antibiotic used to study the inhibition of protein synthesis, bacterial antibiotic resistance, and protein and surfactant binding it is produced by streptomyces lincolnensis var. Lincomycin hydrochloride, chemical structure, molecular. The molecular formula of lincomycin hydrochloride is. Lincomycin hydrochloride w as found to maintain its shelf life at 25c in sodium lactate hartmanns solution, 0. Pdf purpose the purpose of this study was to evaluate the chemical stability of lincocin lincomycin hydrochloride in commonly used. It should be used with caution due to the risk of diarrhoea. Lincocin sterile solution contains lincomycin hydrochloride which is the monohydrated salt of lincomycin, a substance produced by the growth of a member of the.
Where the label states that lincomycin hydrochloride must be subjected to further processing during the preparation of injectable dosage forms,it meets the requirements for bacterial endotoxins under lincomycin injection. Residue depletion study with 14clabelled lincomycin an equal number of 25 days old male and female hubbardcrosshubbard chicks were given water containing 14clincomycin hydrochloride, equivalent to 34 g of lincomycin free baseml specific activity 2. Lincomycin side effects, dosage, interactions drugs. The chemical name for lincomycin hydrochloride is methyl 6,8dideoxy61methyltrans4propyll. Assessing the depletion of lincomycin in feathers from. In a glp conforming study, five groups of two pigs received oral doses of c lincomycin hydrochloride of 440 mg per animal per day by capsule hornish.
The feces of mice were collected in the control stage day 0, with no treatment, modeling stage day 5, with the inoculation of lincomycin hydrochloride, treatment stage day 10, with the drug treatment, and recovery stage day 17, with no management. It should be used only in cases where other medicines are less effective. Stability studies of lincomycin hydrochloride in aqueous. Safety data sheet lincomycin hydrochloride injection, usp. Buy 7epi lincomycin hydrochloride salt cas 26389844, a biochemical for proteomics research, from santa cruz. Stability studies of lincomycin hydrochloride in aqueous solution and intravenous infusion fluids petra czarniak, michael boddy, bruce sunderland, jeff d hughes school of pharmacy, curtin university, perth, wa, australia purpose. Do not use in horses intended for human consumption. The purpose of this study was to evaluate the chemical stability of lincocin lincomycin hydrochloride in commonly used intravenous fluids at room temperature 25.
Directions for use lincomycin hydrochloride soluble powder dosage and administration. Lincomycin is a carbohydratecontaining antibiotic produced by the actinomyces streptomyces lincolnensis. To the monograph and addendum prepared by the 54th and 58th meetings of the committee. Similar discouraging reports regarding topical application of tetracycline in acne turned our attention to two of the few remaining effective antibiotics, lincomycin hydrochloride monohydrate lincocin and clindamycin cleocin.
Find patient medical information for lincomycin oral on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. In topical form, clindamycin is becoming very popular among clinical dermatologists. To report adverse effects, access medical information, or obtain additional product. Lincocin lincomycin hydrochloride should be used with caution in those patients with a history of gastrointestinal disease. Close monitoring of liver and kidney function is necessary while receiving this medicine. Lincomycin hydrochloride soluble powder is indicated for the treatment of swine dysentery bloody scours. Dailymed lincocin lincomycin hydrochloride injection, solution. Lincocin products contain lincomycin hydrochloride, an antibiotic produced by. Lincomycin hydrochloride api dmfs us drug master file. Assessing the depletion of lincomycin in feathers from treated broiler chickens. Each ml of lincocin sterile solution contains lincomycin hydrochloride equivalent to lincomycin 300 mg. Product monograph prlincocin lincomycin injection usp.
It also shouldnt be used to treat nonbacterial infections. Lincomycin hydrochloride injection, usp lincomycin hydrochloride rat oral ld50 1230 mgkg 30 days rat oral 300 mgkgday noael no effects at maximum dose rat oral ld 50 4000 mgkg. Lincomycin is an antibiotic which is used in the treatment of infections caused by bacteria like streptococci, pneumococci, and staphylococci. It is a carbohydratecontaining antibiotic, a sglycosyl compound, a monocarboxylic acid amide, a pyrrolidinecarboxamide and a lproline derivative. Lincomycin hydrochloride is freely soluble in water. A related compound, clindamycin, is derived from lincomycin by using thionyl chloride to replace the 7hydroxy group with a chlorine atom with inversion of chirality. Lincocin lincomycin injection, usp to reduce the development of. This study reports the development and validation of a simple reverse phase chromatographic method using uv detection for the routine analysis and quality control of the combined spectinomycin and lincomycin injectable formulation which contains the active ingredients.
Other information text of r phrases mentioned in section 3 r43 may cause sensitization by skin contact. Lincocin lincomycin hydrochloride product monograph. Following im administration of 600 mg in healthy adults, peak plasma concentrations of 9. Lincomycin binds to the 50s subunit of the bacterial ribosome resulting in the inhibition of protein synthesis and thereby produces bactericidal effects in susceptible organisms. Store at controlled room temperature 20 to 25c 68 to 77f see usp. Lincomycin article about lincomycin by the free dictionary. Feb 27, 2019 lincomycin hydrochloride is a white or practically white, crystalline powder and is odorless or has a faint odor. Lincomycin is a lincosamide antibiotic derived from bacteria streptomyces lincolnensis with activity against gram positive and anaerobic bacteria.
Lincocin lincomycin hcl how suppliedstorage and handling. Lincocin lincomycin dosing, indications, interactions. Lincomycin hydrochloride zoetis oel twa 8hr 100gm3 estonia oel twa 2 mgm3 silicon dioxide, colloidal nf finland oel twa 5 mgm3 revision date. Lincomycin hydrochloride soluble powder is indicated for the control of necrotic enteritis caused by clostridium perfringens susceptible to lincomycin. Cleocin hclclindamycin hydrochloridecapsules, usp page 1. The lincomycin hydrochloride market has encountered significant development in the recent years and is anticipated to grow tremendously over the forecast period. Lincomycin hydrochloride skin irritation guinea pig moderate benzyl alcohol material name.
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